Peripheral fat loss and decline in adipogenesis in older humans.

ABSTRACT:

Objective

Aging is associated with a redistribution of body fat including a relative loss of subcutaneous peripheral fat. These changes in body fat can have important clinical consequences since they are linked to increased risk of metabolic complications. The causes and mechanisms of loss of peripheral fat associated with aging are not clear. The aim of this study was to assess whether defects in adipogenesis contribute to fat loss in aging humans, as suggested from animal studies, and to evaluate the role of inflammation on pathogenesis of fat loss.

Materials/methods

Preadipocytes isolated from subcutaneous peripheral fat of healthy young and elderly subjects were compared in their ability to replicate and differentiate.

Results

The results show that both the rate o

SUBMITTER: Caso G 

PROVIDER: S-EPMC3531563 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature