Use of natural molecules as anti-angiogenic inhibitors for vascular endothelial growth factor receptor.

ABSTRACT: Angiogenesis refers to the formation of new blood vessels, controlled by certain chemicals, which on stimulation repairs damaged cells or form new ones. Other chemicals, called angiogenesis inhibitors, signal the process to stop, having only mild side effects and are non toxic to most healthy cells. In our study, attempt was made to find potent anti-angiogenic inhibitor (pazopanib was considered as a reference drug) for vascular endothelial growth factor receptor (VEGFR-1/FLT-1), which served as a molecular target, using natural agents targeting biological processes important in cancer. Hundreds of natural molecules were initially screened based on lipinski's rule of five and the satisfying ones were taken for receptor-ligand interaction study using docking tools like HEX and quantum. Arou

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC3532009 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature