Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3532028 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Li Yan Y Ge Chunxi C Long Jason P JP Begun Dana L DL Rodriguez Jose A JA Goldstein Steven A SA Franceschi Renny T RT
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120601 6
Bone can adapt its structure in response to mechanical stimuli. At the cellular level, this involves changes in chromatin organization, gene expression, and differentiation, but the underlying mechanisms are poorly understood. Here we report on the involvement of RUNX2, a bone-related transcription factor, in this process. Fluid flow shear stress loading of preosteoblasts stimulated translocation of extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) to the nucleu ...[more]