Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial).

ABSTRACT:

Background

The use of mother's own breast milk during initial hospitalization has a positive impact not only in reducing potential serious neonatal morbidities but also contribute to improvements in neurodevelopmental outcomes. Mothers of very preterm infants struggle to maintain a supply of breast milk during their infants' prolonged hospitalization. Galactogogues are medications that induce lactation by exerting its effects through oxytocin or prolactin enhancement. Domperidone is a potent dopamine D2 receptor antagonist which stimulates the release of prolactin. Small trials have established its ability in enhancing breast milk production. EMPOWER was designed to determine the safety and efficacy of domperidone in mothers experiencing an inadequate milk supply.

Methods/design

SUBMITTER: Asztalos EV 

PROVIDER: S-EPMC3532128 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature