Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer.

ABSTRACT:

Background

Cell line models have proven to be effective tools to investigate a variety of ovarian cancer features. Due to the limited number of cell lines, particularly of the serous subtype, the heterogeneity of the disease, and the lack of cell lines that model disease progression, there is a need to further develop cell line resources available for research. This study describes nine cell lines derived from three ovarian cancer cases that were established at initial diagnosis and at subsequent relapse after chemotherapy.

Methods

The cell lines from three women diagnosed with high-grade serous ovarian cancer (1369, 2295 and 3133) were derived from solid tumor (TOV) and ascites (OV), at specific time points at diagnosis and relapse (R). Primary treatment was a combination o

SUBMITTER: Letourneau IJ 

PROVIDER: S-EPMC3532154 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature