Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level.

ABSTRACT:

Background

E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.

Methods

Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.

Results

SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 l

SUBMITTER: Wu S 

PROVIDER: S-EPMC3532335 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature