Evidence for sequence biases associated with patterns of histone methylation.

ABSTRACT:

Background

Combinations of histone variants and modifications, conceptually representing a histone code, have been proposed to play a significant role in gene regulation and developmental processes in complex organisms. While various mechanisms have been implicated in establishing and maintaining epigenetic patterns at specific locations in the genome, they are generally believed to be independent of primary DNA sequence on a more global scale.

Results

To address this systematically in the case of the human genome, we have analyzed primary DNA sequences underlying patterns of 19 different methylated histones in human primary T-cells and patterns of three methylated histones across additional human cell lines. We report strong sequence biases associated with most of these his

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3532361 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature