From expression pattern to genetic association in asthma and asthma-related phenotypes.

ABSTRACT:

Background

Asthma is a complex disease characterized by hyperresponsiveness, obstruction and inflammation of the airways. To date, several studies using different approaches as candidate genes approach, genome wide association studies, linkage analysis and genomic expression leaded to the identification of over 300 genes involved in asthma pathophysiology. Combining results from two studies of genomic expression, this study aims to perform an association analysis between genes differently expressed in bronchial biopsies of asthmatics compared to controls and asthma-related phenotypes using the same French-Canadian Caucasian population.

Results

Before correction, 31 of the 85 genes selected were associated with at least one asthma-related phenotype. We found four genes that s

SUBMITTER: Vaillancourt VT 

PROVIDER: S-EPMC3532380 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature