Genomic and gene-level distribution of histone H3 dimethyl lysine-27 (H3K27me2) in Arabidopsis.

ABSTRACT: Histone lysine methylation patterns underlie much of the functional diversity of nucleosomes in eukaryotes, and an interesting aspect of histone methylation is the potential functional specificity for different methylation states on a given lysine. Trimethylation of histone H3 (H3K27me3) is intimately related to developmental gene silencing through the so-called Polycomb Group (PcG) mechanism. How this modification becomes established at PcG-repressed loci is generally not known, but it has been suggested that it may be facilitated by prior occupancy by H3K27me2. In this study we mapped the genomic and gene-level distribution of H3K27me2 in Arabidopsis thaliana using ChIP and a high-density tiling microarray, and integrated this with previous maps of other chromatin features and gene expre

SUBMITTER: Park S 

PROVIDER: S-EPMC3532402 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature