INOS activation regulates β-catenin association with its partners in endothelial cells.

ABSTRACT:

Background

Signals that disrupt β-catenin association to cadherins may influence the translocation of β-catenin to the nucleus to regulate transcription. Post-translational modification of proteins is a signalling event that may lead to changes in structural conformation, association or function of the target proteins. NO and its derivatives induce nitration of proteins during inflammation. It has been described that animals treated with NO donors showed increased permeability due to modulation of VE-cadherin/catenin complex. We, therefore, aim to evaluate the effect of iNOS activation on the expression, nuclear localisation and function of β-catenin in endothelial cells.

Methodology/principal findings

Expression, nuclear localisation, post-translational modifications and fu

SUBMITTER: Gonzalez D 

PROVIDER: S-EPMC3532412 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature