Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.

ABSTRACT: Human and animal studies demonstrate that short sleep or poor sleep quality, e.g. in night shift workers, promote the development of obesity and diabetes. Effects of sleep disruption on glucose homeostasis and liver physiology are well documented. However, changes in adipokine levels after sleep disruption suggest that adipocytes might be another important peripheral target of sleep. Circadian clocks regulate metabolic homeostasis and clock disruption can result in obesity and the metabolic syndrome. The finding that sleep and clock disruption have very similar metabolic effects prompted us to ask whether the circadian clock machinery may mediate the metabolic consequences of sleep disruption. To test this we analyzed energy homeostasis and adipocyte transcriptome regulation in a mouse mod

SUBMITTER: Husse J 

PROVIDER: S-EPMC3532432 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature