A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations.

ABSTRACT:

Background

Elevated soluble (s) E-selectin levels have been associated with various cardiovascular diseases. Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is reproducible in two large samples of Caucasians.

Methodology/ principal findings

Data of the present study was drawn from the population-based MONICA/KORA Augsburg study (n = 1,482) and the patients-based LURIC study (n = 1,546). A high-density genotyping array (50K IBC Chip) containing single-nucleotide polymorphisms (SNPs) from E-selectin candidate genes selected on known biology of E-selectin metabolism, mouse genetic studies, and human genetic association studies, was used for genotypi

SUBMITTER: Karakas M 

PROVIDER: S-EPMC3532506 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature