Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata.

ABSTRACT: Infection of bovine leucocytes by Theileria annulata results in establishment of transformed, infected cells. Infection of the host cell is known to promote constitutive activation of pro-inflammatory transcription factors that have the potential to be beneficial or detrimental. In this study we have compared the effect of LPS activation on uninfected bovine leucocytes (BL20 cells) and their Theileria-infected counterpart (TBL20). Gene expression profiles representing activated uninfected BL20 relative to TBL20 cells were also compared. The results show that while prolonged stimulation with LPS induces cell death and activation of NF-κB in BL20 cells, the viability of Theileria-infected cells was unaffected. Analysis of gene expression networks provided evidence that the parasite establish

SUBMITTER: Durrani Z 

PROVIDER: S-EPMC3532605 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature