Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts.

ABSTRACT:

Background

Little evidence on the validity of simple and widely applicable tools to predict mortality in patients with chronic obstructive pulmonary disease (COPD) exists.

Objective

To conduct a large international study to validate the ADO index that uses age, dyspnoea and FEV(1) to predict 3-year mortality and to update it in order to make prediction of mortality in COPD patients as generalisable as possible.

Design

Individual subject data analysis of 10 European and American cohorts (n=13 914).

Setting

Population-based, primary, secondary and tertiary care.

Patients

COPD GOLD stages I-IV.

Measurements

We validated the original ADO index. We then obtained an updated ADO index in half of our cohorts to improve its predictive accuracy, which in tu

SUBMITTER: Puhan MA 

PROVIDER: S-EPMC3533065 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature