Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions.

ABSTRACT:

Background

Drug interactions in oncology are common place and largely ignored as we tolerate high thresholds of 'toxic' drug responses in these patients. However, in the era of 'targeted' or seemingly 'less toxic' therapy, these interactions are more commonly flagged and contribute significantly towards poor 'quality of life' and medical fatalities.

Objective

This review and opinion article focuses on alteration of chemotherapeutic pharmacokinetic profiles by drug interactions in the setting of polypharmacy. The assumption is that the drugs, with changes in their pharmacokinetics, will contribute towards changes in their pharmacodynamics.

Methods

The examples cited for such drug-drug interactions are culled from published literature with an emphasis on those interacti

SUBMITTER: Mani S 

PROVIDER: S-EPMC3533254 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature