Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions.

ABSTRACT: Thyroid hormone is well known for its profound direct effects on cardiovascular function and metabolism. Recent evidence, however, suggests that the hormone also regulates these systems indirectly through the central nervous system. While some of the molecular mechanisms underlying the hormone's central control of metabolism have been identified, its actions in the central cardiovascular control have remained enigmatic. Here, we describe a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus that requires thyroid hormone receptor signaling for proper development. Specific stereotaxic ablation of these cells in the mouse resulted in hypertension and temperature-dependent tachycardia, indicating a role in the central autonomic control of blood pressure and h

SUBMITTER: Mittag J 

PROVIDER: S-EPMC3533300 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature