Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas.

ABSTRACT:

Background

On the past decade a plethora of investigations were directed on identification of molecules involved in breast tumorogenesis, which could represent a powerful tool for monitoring, diagnostics and treatment of this disease. In current study we analyzed six previously identified medullary breast carcinoma autoantigens including LGALS3BP, RAD50, FAM50A, RBPJ, PABPC4, LRRFIP1 with cancer restricted serological profile in different histological types of breast cancer.

Methods

Semi-quantitative immunohistochemical analysis of 20 tissue samples including medullary breast carcinoma, invasive ductal carcinoma, invasive lobular carcinoma and non-cancerous tissues obtained from patients with fibrocystic disease (each of five) was performed using specifically generated polyc

SUBMITTER: Kostianets O 

PROVIDER: S-EPMC3533517 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature