Ontology highlight
ABSTRACT:
SUBMITTER: Alberich-Jorda M
PROVIDER: S-EPMC3533560 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20121119 12
C/EBPs are a family of transcription factors that regulate growth control and differentiation of various tissues. We found that C/EBPγ is highly upregulated in a subset of acute myeloid leukemia (AML) samples characterized by C/EBPα hypermethylation/silencing. Similarly, C/EBPγ was upregulated in murine hematopoietic stem/progenitor cells lacking C/EBPα, as C/EBPα mediates C/EBPγ suppression. Studies in myeloid cells demonstrated that CEBPG overexpression blocked neutrophilic differentiation. Fu ...[more]