Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

ABSTRACT: Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.

SUBMITTER: Brandmayr C 

PROVIDER: S-EPMC3533783 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature