Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.
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ABSTRACT:
SUBMITTER: Brandmayr C
PROVIDER: S-EPMC3533783 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.
Brandmayr Caterina C Wagner Mirko M Brückl Tobias T Globisch Daniel D Pearson David D Kneuttinger Andrea Christa AC Reiter Veronika V Hienzsch Antje A Koch Susanne S Thoma Ines I Thumbs Peter P Michalakis Stylianos S Müller Markus M Biel Martin M Carell Thomas T
Angewandte Chemie (International ed. in English) 20121004 44
Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency. ...[more]
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