Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort.

ABSTRACT:

Background

Air pollution is associated with asthma exacerbations. We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure.

Methods

This study was embedded in the Generation R Study, a population-based prospective cohort study among 4,634 children. PM10 and NO2 levels were estimated for the home addresses using dispersion modeling. Annual parental reports of wheezing until the age of 3 years and fetal and infant tobacco smoke exposure was obtained by questionnaires.

Results

Average annual PM10 or NO2 exposure levels per year were not associated with wheezing in the same year. Longitudinal analy

SUBMITTER: Sonnenschein-van der Voort AM 

PROVIDER: S-EPMC3533997 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature