SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.

ABSTRACT: A major component of the cardiac stress response is the simultaneous activation of several gene regulatory networks. Interestingly, the transcriptional regulator steroid receptor coactivator-2, SRC-2 is often decreased during cardiac failure in humans. We postulated that SRC-2 suppression plays a mechanistic role in the stress response and that SRC-2 activity is an important regulator of the adult heart gene expression profile. Genome-wide microarray analysis, confirmed with targeted gene expression analyses revealed that genetic ablation of SRC-2 activates the "fetal gene program" in adult mice as manifested by shifts in expression of a) metabolic and b) sarcomeric genes, as well as associated modulating transcription factors. While these gene expression changes were not accompanied by ch

SUBMITTER: Reineke EL 

PROVIDER: S-EPMC3534027 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature