Associations of common variants at APLN and hypertension in Chinese subjects with and without diabetes.

ABSTRACT:

Background

Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo. The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.

Methods

Three single nucleotide polymorphisms (SNPs) on APLN were genotyped in 3156 diabetic patients and 3736 nondiabetic individuals. For non-diabetic subjects, 1779 were enrolled in stage 1 and 1757 were recruited for validation. A meta-analysis combining the two stages was carried out to obtain the overall effect.

Results

In diabetic patients, no significant associations of the three SNPs with hypertension were observed.

SUBMITTER: Zhang R 

PROVIDER: S-EPMC3534217 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature