Sequencing and analysis of a South Asian-Indian personal genome.

ABSTRACT:

Background

With over 1.3 billion people, India is estimated to contain three times more genetic diversity than does Europe. Next-generation sequencing technologies have facilitated the understanding of diversity by enabling whole genome sequencing at greater speed and lower cost. While genomes from people of European and Asian descent have been sequenced, only recently has a single male genome from the Indian subcontinent been published at sufficient depth and coverage. In this study we have sequenced and analyzed the genome of a South Asian Indian female (SAIF) from the Indian state of Kerala.

Results

We identified over 3.4 million SNPs in this genome including over 89,873 private variations. Comparison of the SAIF genome with several published personal genomes revealed tha

SUBMITTER: Gupta R 

PROVIDER: S-EPMC3534380 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature