Gene autoregulation via intronic microRNAs and its functions.

ABSTRACT:

Background

MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases. This paper focus on a minimal microRNA-mediated regulatory circuit, in which a protein-coding gene (host gene) is targeted by a microRNA located inside one of its introns.

Results

Autoregulation via intronic microRNAs is widespread in the human regulatory network, as confirmed by our bioinformatic analysis, and can perform several regulatory tasks despite its simple topology. Our analysis, based on analytical calculations and simulations, indicates that this circuitry alters the dynamics of the host gene expression, can induce complex re

SUBMITTER: Bosia C 

PROVIDER: S-EPMC3534558 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature