The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite's biology.

ABSTRACT:

Background

Schistosoma mansoni is one of the causative agents of schistosomiasis, a neglected tropical disease that affects about 237 million people worldwide. Despite recent efforts, we still lack a general understanding of the relevant host-parasite interactions, and the possible treatments are limited by the emergence of resistant strains and the absence of a vaccine. The S. mansoni genome was completely sequenced and still under continuous annotation. Nevertheless, more than 45% of the encoded proteins remain without experimental characterization or even functional prediction. To improve our knowledge regarding the biology of this parasite, we conducted a proteome-wide evolutionary analysis to provide a broad view of the S. mansoni's proteome evolution and to improve its functi

SUBMITTER: Silva LL 

PROVIDER: S-EPMC3534613 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature