Learning and memory following conformal radiation therapy for pediatric craniopharyngioma and low-grade glioma.

ABSTRACT:

Purpose

The primary objective of this study was to examine whether children with low-grade glioma (LGG) or craniopharyngioma had impaired learning and memory after conformal radiation therapy (CRT). A secondary objective was to determine whether children who received chemotherapy before CRT, a treatment often used to delay radiation therapy in younger children with LGG, received any protective benefit with respect to learning.

Methods and materials

Learning and memory in 57 children with LGG and 44 children with craniopharyngioma were assessed with the California Verbal Learning Test-Children's Version and the Visual-Auditory Learning tests. Learning measures were administered before CRT, 6 months later, and then yearly for a total of 5 years.

Results

No decline in le

SUBMITTER: Di Pinto M 

PROVIDER: S-EPMC3534785 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature