Clinical and environmental influences on metabolic biomarkers collected for newborn screening.

ABSTRACT:

Objectives

Identifying common clinical and environmental factors that influence newborn metabolic biomarkers will improve the utilization of metabolite panels for clinical diagnostic medicine.

Design and methods

Environmental effects including gender, season of birth, gestational age, birth weight, feeding method and age at time of collection were evaluated for over 50 metabolites collected by the Iowa Neonatal Metabolic Screening Program on 221,788 newborns over a six year period.

Results

We replicated well known observations that low birth weight and preterm infants have higher essential amino acids and lower medium and long chain acylcarnitine levels than their term counterparts. Smaller, but still significant, differences were observed for gender and timing of sam

SUBMITTER: Ryckman KK 

PROVIDER: S-EPMC3534803 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature