Ontology highlight
ABSTRACT:
SUBMITTER: Delviks-Frankenberry KA
PROVIDER: S-EPMC3534945 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Virology 20121013 2
Mutations in the connection subdomain (CN) and RNase H domain (RH) of HIV-1 reverse transcriptase (RT) from subtype B-infected patients enhance nucleoside and nonnucleoside RT inhibitor (NRTI and NNRTI) resistance by affecting the balance between polymerization and RNase H activity. To determine whether CN mutations in subtype C influence drug sensitivity, single genome sequencing was performed on Brazilian subtype C-infected patients failing RTI therapy. CN mutations identified were similar to ...[more]