Current status on genome-metabolome-wide associations: an opportunity in nutrition research.

ABSTRACT: Genome-wide association studies (GWASs) have become a very important tool to address the genetic origin of phenotypic variability, in particular associated with diseases. Nevertheless, these types of studies provide limited information about disease etiology and the molecular mechanisms involved. Recently, the incorporation of metabolomics into the analysis has offered novel opportunities for a better understanding of disease-related metabolic deregulation. The pattern emerging from this work is that gene-driven changes in metabolism are prevalent and that common genetic variations can have a profound impact on the homeostatic concentrations of specific metabolites. A particularly interesting aspect of this work takes into account interactions of environment and lifestyle with the genome a

SUBMITTER: Montoliu I 

PROVIDER: S-EPMC3534994 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature