Patterns of deficits in brain function in bipolar disorder and schizophrenia: a cluster analytic study.

ABSTRACT: Historically, bipolar disorder and schizophrenia have been considered distinct disorders with different etiologies. Growing evidence suggests that overlapping genetic influences contribute to risk for these disorders and that each disease is genetically heterogeneous. Using cluster analytic methods, we empirically identified homogeneous subgroups of patients, their relatives, and controls based on distinct neurophysiologic profiles. Seven phenotypes were collected from two independent cohorts at two institutions. K-means clustering was used to identify neurophysiologic profiles. In the analysis of all participants, three distinct profiles emerged: "globally impaired", "sensory processing", and "high cognitive". In a secondary analysis, restricted to patients only, we observed a similar clu

SUBMITTER: Hall MH 

PROVIDER: S-EPMC3535009 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature