Ontology highlight
ABSTRACT:
SUBMITTER: Gregersen PK
PROVIDER: S-EPMC3535539 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Gregersen Peter K PK Kosoy Roman R Lee Annette T AT Lamb Janine J Sussman Jon J McKee David D Simpfendorfer Kim R KR Pirskanen-Matell Ritva R Piehl Frederik F Pan-Hammarstrom Qiang Q Verschuuren Jan J G M JJ Titulaer Maarten J MJ Niks Erik H EH Marx Alexander A Ströbel Philipp P Tackenberg Björn B Pütz Michael M Maniaol Angelina A Elsais Ahmed A Tallaksen Chantal C Harbo Hanne F HF Lie Benedicte A BA Raychaudhuri Soumya S de Bakker Paul I W PI Melms Arthur A Garchon Henri-Jean HJ Willcox Nicholas N Hammarstrom Lennart L Seldin Michael F MF
Annals of neurology 20121010 6
<h4>Objective</h4>The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).<h4>Methods</h4>We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases were matched 1:4 with controls of European ancestry. We performed imputation and conditional analyses across the major histocompatibility complex, as well as in the top regions of association outside the human leukocyte antigen (HLA) reg ...[more]