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Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

ABSTRACT: Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.

SUBMITTER: Chenoweth DM 

PROVIDER: S-EPMC3535541 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

Chenoweth David M DM   Meier Jordan L JL   Dervan Peter B PB  

Angewandte Chemie (International ed. in English) 20120914 1

Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented. ...[more]

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