Early childhood infection of Kaposi's sarcoma-associated herpesvirus in Zambian households: a molecular analysis.

ABSTRACT: Sub-Saharan Africa is endemic for Kaposi's sarcoma-associated herpesvirus (KSHV) and there is a high rate of early childhood infection; however, the transmission sources are not well characterized. We examined household members as potential KSHV transmission sources to young children in the KSHV-endemic country of Zambia. To this end, we enrolled and followed Zambian households with at least one KSHV-seropositive child and collected longitudinal buccal swab samples. KSHV burden was evaluated and K1 sequences from the children were determined and analyzed for differences to K1 sequences from household members. The K1 sequences were also analyzed for evolution over time. We generated K1 sequences from 31 individuals across 16 households. Nine households contained multiple KSHV-positive membe

SUBMITTER: Olp LN 

PROVIDER: S-EPMC3535687 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature