VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus infections caused by strains that are resistant to all forms of penicillin, so-called methicillin-resistant S. aureus (MRSA) strains, have become common. One strategy to counter MRSA infections is to use compounds that resensitize MRSA to methicillin. S. aureus responds to diverse classes of cell wall-inhibitory antibiotics, like methicillin, using the two-component regulatory system VraSR (vra) to up- or downregulate a set of genes (the cell wall stimulon) that presumably facilitates resistance to these antibiotics. Accordingly, VraS and VraR mutations decrease resistance to methicillin, vancomycin, and daptomycin cell wall antimicrobials. vraS and vraR are encoded together on a transcript downstream of two other genes, which we call vraU and vraT (previously called

SUBMITTER: Boyle-Vavra S 

PROVIDER: S-EPMC3535960 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature