Point: is the era of viral culture over in the clinical microbiology laboratory?

ABSTRACT: Conventional tube culture systems have long been the mainstay in clinical virology for the growth and identification of viruses from clinical specimens. Innovations such as centrifugation-enhanced shell vial and multiwell plate cultures and the use of genetically engineered and mixed cell lines, coupled with faster detection of viral replication, have allowed for reasonable turnaround times for even some of the most slowly growing clinically important human viruses. However, molecular methods, in particular, the PCR, have usurped the role of viral culture in many laboratories, limiting the use of this traditional method of virus detection or replacing it altogether. Advances and improvements in molecular technology over time have also resulted in newer generations of more rapid and accurat

SUBMITTER: Hodinka RL 

PROVIDER: S-EPMC3536207 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature