Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium.

ABSTRACT:

Background

The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes.

Results

We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by Br

SUBMITTER: Cunha C 

PROVIDER: S-EPMC3536589 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature