Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.

ABSTRACT:

Context

Fat distribution differs in men and women, but in both sexes, a predominantly gluteal-femoral compared with abdominal (central) fat distribution is associated with lower metabolic risk. Differences in cellular characteristics and metabolic functions of these depots have been described, but the molecular mechanisms involved are not understood.

Objective

Our objective was to identify depot- and sex-dependent differences in gene expression in human abdominal and gluteal sc adipose tissues.

Design and methods

Abdominal and gluteal adipose tissue aspirates were obtained from 14 premenopausal women [age 27.5 ± 7.0 yr, body mass index (BMI) 27.3 ± 6.2 kg/m(2), and waist-to-hip ratio 0.82 ± 0.04] and 21 men (age 29.7±7.4 yr, BMI 27.2 ± 4.5 kg/m(2), and waist-to-hip ra

SUBMITTER: Karastergiou K 

PROVIDER: S-EPMC3537084 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature