Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.

ABSTRACT:

Context

Cold exposure stimulates fibroblast growth factor 21 (FGF21) secretion in animals, enhancing the cold-induced thermogenesis (CIT) response through browning of white adipose tissue. In humans, the effects of cold exposure on circulating FGF21 levels are unknown.

Objective

Our objective was to evaluate the effects of mild cold exposure on circulating FGF21 and its relationship with CIT and lipolysis in humans.

Design and setting

We conducted a randomized, single-blind, crossover intervention study at the National Institutes of Health Clinical Center.

Participants

Participants were healthy adults.

Intervention

Subjects were exposed to a 12-h exposure to 24 or 19 C in a whole-room indirect calorimeter.

Outcome measures

Energy expenditure, plas

SUBMITTER: Lee P 

PROVIDER: S-EPMC3537100 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature