Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study.

ABSTRACT:

Background

Obesity is a highly heritable disease defined by high body mass index (BMI). However, a large proportion of the heritability of obesity remains unexplained. Copy number variations (CNVs) might contribute to the missing heritability of obesity.

Methods

We conducted genome-wide CNV analyses on obesity phenotypes, including BMI and body fat mass in a discovery sample of 2215 unrelated white subjects. After quality control, 314 CNVs were used for association tests. For significant CNVs identified, follow-up replication analyses were performed in three independent samples, including an unrelated sample of 1000 white subjects (OM sample), a family-based sample of 8385 white subjects (FHS sample), and an African-American sample of 1479 obesity cases and 1575 lean control

SUBMITTER: Yang TL 

PROVIDER: S-EPMC3537105 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature