Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.

ABSTRACT:

Context

A previous genome-wide association study in Chinese women with polycystic ovary syndrome (PCOS) identified a region on chromosome 2p16.3 encoding the LH/choriogonadotropin receptor (LHCGR) and FSH receptor (FSHR) genes as a reproducible PCOS susceptibility locus.

Objective

The objective of the study was to determine the role of the LHCGR and/or FSHR gene in the etiology of PCOS in women of European ancestry.

Design

This was a genetic association study in a European ancestry cohort of women with PCOS.

Setting

The study was conducted at an academic medical center.

Participants

Participants in the study included 905 women with PCOS diagnosed by National Institutes of Health criteria and 956 control women.

Intervention

We genotyped 94 haplotyp

SUBMITTER: Mutharasan P 

PROVIDER: S-EPMC3537106 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature