Therapy of hypoparathyroidism with PTH(1-84): a prospective four-year investigation of efficacy and safety.

ABSTRACT:

Context

PTH may be an effective treatment option for hypoparathyroidism, but long-term data are not available.

Objective

We studied the effect of 4 yr of PTH(1-84) treatment in hypoparathyroidism.

Design

Twenty-seven subjects were treated with PTH(1-84) for 4 yr, with prospective monitoring of calcium and vitamin D requirements, serum and urinary calcium, serum phosphorus, bone turnover markers, and bone mineral density (BMD).

Results

Treatment with PTH(1-84) reduced supplemental calcium requirements by 37% (P = 0.006) and 1,25-dihydroxyvitamin D requirements by 45% (P = 0.008). Seven subjects (26%) were able to stop 1,25-dihydroxyvitamin D completely. Serum calcium concentration remained stable, and urinary calcium and phosphorus excretion fell. Lumbar spine B

SUBMITTER: Cusano NE 

PROVIDER: S-EPMC3537109 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature