Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes.

ABSTRACT:

Context

Genetic factors play a major role in the etiology of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT). We have previously identified three loci on chromosomes 10q, 12q, and 14q that showed strong linkage with AITD, HT, and GD, respectively.

Objectives

The objective of the study was to identify the AITD susceptibility genes at the 10q, 12q, and 14q loci.

Design and participants

Three hundred forty North American Caucasian AITD patients and 183 healthy controls were studied. The 10q, 12q, and 14q loci were fine mapped by genotyping densely spaced single-nucleotide polymorphisms (SNPs) using the Illumina GoldenGate genotyping platform. Case control association analyses were performed using the UNPHASED computer pac

SUBMITTER: Tomer Y 

PROVIDER: S-EPMC3537111 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature