Ontology highlight
ABSTRACT:
SUBMITTER: Giulino-Roth L
PROVIDER: S-EPMC3537311 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Blood 20121022 26
To ascertain the genetic basis of pediatric Burkitt lymphoma (pBL), we performed clinical-grade next-generation sequencing of 182 cancer-related genes on 29 formalin-fixed, paraffin embedded primary pBL samples. Ninety percent of cases had at least one mutation or genetic alteration, most commonly involving MYC and TP53. EBV(-) cases were more likely than EBV(+) cases to have multiple mutations (P < .0001). Alterations in tumor-related genes not previously described in BL were identified. Trunca ...[more]