Human papillomavirus genotype attribution and estimation of preventable fraction of anal intraepithelial neoplasia cases among HIV-infected men who have sex with men.

ABSTRACT:

Background

The prevention of human papillomavirus (HPV)-induced anal cancer in high-risk populations such as human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) remains an urgent priority, given rising incidence rates despite widespread antiretroviral therapy use.

Methods

HPV genotypes and anal disease prevalence, by cytology and histopathologic findings, were evaluated among 363 HIV-infected MSM. We modeled fractions of high-grade anal intraepithelial neoplasia (HGAIN) attributable to individual carcinogenic HPV genotypes and estimated the range of the proportion of HGAIN cases potentially preventable by prophylactic HPV vaccines.

Results

HPV16 was the most common genotype overall (26.4% of cases) and among HGAIN cases (55%). Prevalence of mul

SUBMITTER: Sahasrabuddhe VV 

PROVIDER: S-EPMC3537447 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature