A multicellular basis for the origination of blast crisis in chronic myeloid leukemia.

ABSTRACT: Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology is considered comparatively well understood. Thus, quantitative analysis of CML and its progression to blast crisis may help elucidate general mechanisms of carcinogenesis and cancer progression. Hitherto, it has been widely postulated that CML blast crisis originates mainly via cell-autonomous mechanisms such as secondary mutations or genomic instability. However, recent results suggest that carcinogenic transformation may be an inherently multicellular event, in departure from the classic unicellular paradigm. We investigate this possibility in the case of blast crisis origination in CML. A quantitative, mechanistic cell population dynamics model was employed. This model used rece

SUBMITTER: Sachs RK 

PROVIDER: S-EPMC3537493 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature