Production of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein family.

ABSTRACT:

Background

Glycopeptidolipids (GPLs) are among the major free glycolipid components of the outer membrane of several saprophytic and clinically-relevant Mycobacterium species. The architecture of GPLs is based on a constant tripeptide-amino alcohol core of nonribosomal peptide synthetase origin that is N-acylated with a 3-hydroxy/methoxy acyl chain synthesized by a polyketide synthase and further decorated with variable glycosylation patterns built from methylated and acetylated sugars. GPLs have been implicated in many aspects of mycobacterial biology, thus highlighting the significance of gaining an understanding of their biosynthesis. Our bioinformatics analysis revealed that every GPL biosynthetic gene cluster known to date contains a gene (referred herein to as gplH) encoding

SUBMITTER: Tatham E 

PROVIDER: S-EPMC3537567 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature