Titanocene / cyclodextrin supramolecular systems: a theoretical approach.

ABSTRACT:

Unlabelled

Background

Recently, various metallocenes were synthesized and analyzed by biological activity point of view (such as antiproliferative properties): ruthenocenes, cobaltoceniums, titanocenes, zirconocenes, vanadocenes, niobocenes, molibdocenes etc. Two main disadvantages of metallocenes are the poor hydrosolubility and the hydrolytic instability. These problems could be resolved in two ways: synthetically modifying the structure or finding new formulations with enhanced properties. The aqueous solubility of metallocenes with cytostatic activities could be enhanced by molecular encapsulation in cyclodextrins, as well as the hydrolytic instability of these compounds could be reduced.

Results

This study presents a theoretical approach on the nanoencapsulation

SUBMITTER: Rivis A 

PROVIDER: S-EPMC3537657 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature