Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.

ABSTRACT:

Background

Adolescent idiopathic scoliosis (AIS) is one of the most common spinal deformities found in adolescent populations. Recently, a genome-wide association study (GWAS) in a Japanese population indicated that three single nucleotide polymorphisms (SNPs), rs11190870, rs625039 and rs11598564, all located near the LBX1 gene, may be associated with AIS susceptibility [1]. This study suggests a novel AIS predisposition candidate gene and supports the hypothesis that somatosensory functional disorders could contribute to the pathogenesis of AIS. These findings warrant replication in other populations.

Methodology/principal findings

First, we conducted a case-control study consisting of 953 Chinese Han individuals from southern China (513 patients and 440 healthy controls),

SUBMITTER: Gao W 

PROVIDER: S-EPMC3537668 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature