Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast.

ABSTRACT: The study of systems genetics is changing the way the genetic and molecular basis of phenotypic variation, such as disease susceptibility and drug response, is being analyzed. Moreover, systems genetics aids in the translation of insights from systems biology into genetics. The use of systems genetics enables greater attention to be focused on the potential impact of genetic perturbations on the molecular states of networks that in turn affects complex traits. In this study, we developed models to detect allele-specific perturbations on interactions, in which a genetic locus with alternative alleles exerted a differing influence on an interaction. We utilized the models to investigate the dynamic behavior of an integrated molecular network undergoing genetic perturbations in yeast. Our res

SUBMITTER: Zhang F 

PROVIDER: S-EPMC3537669 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature