GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers.

ABSTRACT:

Background

Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin lymphoma (HL), the aim of this study was to investigate the expression of proteins involved in the regulation of glucose metabolism in the different HL subtypes and their impact on clinical outcome.

Methods

Lymph node biopsies from 54 HL cases and reactive lymphoid tissue were stained for glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA) and lactate exporter proteins MCT1 and MCT4. In a second series, samples from additional 153 HL cases with available clinical data were stained for GLUT1 and LDHA.

Results

Membrane bound GLUT1 expression

SUBMITTER: Hartmann S 

PROVIDER: S-EPMC3537691 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature